Detailed view for PF3D7_0614500

Basic information

TDR Targets ID: 4496
Plasmodium falciparum, 60S ribosomal protein L19
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 11.9161 | Length (AA): 182 | MW (Da): 21580 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01280   Ribosomal protein L19e

Gene Ontology

Mouse over links to read term descriptions.
GO:0022625   cytosolic large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 156 1vq8 (P) 1 142 37.00 0 1 1.04 0.37
1 141 1vq8 (P) 1 141 38.00 0 1 1.25843 -0.11
134 179 4o9b (A) 283 333 20.00 0.44 0.01 0.476447 -1.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_126940)

Species Accession Gene Product
Arabidopsis thaliana AT1G02780   60S ribosomal protein L19-1
Arabidopsis thaliana AT4G02230   60S ribosomal protein L19-3
Arabidopsis thaliana AT3G16780   60S ribosomal protein L19-2
Babesia bovis BBOV_I003160   60S ribosomal protein L19, putative
Brugia malayi Bm1_34025   60S ribosomal protein L19
Caenorhabditis elegans CELE_C09D4.5   Protein RPL-19
Cryptosporidium hominis Chro.30429   60S ribosomal protein L19
Cryptosporidium parvum cgd3_3790   60S ribosomal protein L19
Dictyostelium discoideum DDB_G0281565   S60 ribosomal protein L19
Drosophila melanogaster Dmel_CG2746   Ribosomal protein L19
Echinococcus granulosus EgrG_000771900   ribosomal protein L19
Echinococcus granulosus EgrG_000772100   ribosomal protein L19
Entamoeba histolytica EHI_110340   60S ribosomal protein L19, putative
Entamoeba histolytica EHI_096850   60S ribosomal protein L19, putative
Echinococcus multilocularis EmuJ_000771900   ribosomal protein L19
Echinococcus multilocularis EmuJ_000772100   ribosomal protein L19
Giardia lamblia GL50803_16431   Ribosomal protein L19
Homo sapiens ENSG00000108298   ribosomal protein L19
Leishmania braziliensis LbrM.06.0410   60S ribosomal protein L19, putative
Leishmania braziliensis LbrM.06.0390   60S ribosomal protein L19, putative
Leishmania donovani LdBPK_060410.1   60S ribosomal protein L19, putative
Leishmania infantum LinJ.06.0430   60S ribosomal protein L19, putative
Leishmania infantum LinJ.06.0410   60S ribosomal protein L19, putative
Leishmania major LmjF.06.0415   60S ribosomal protein L19, putative
Leishmania major LmjF.06.0410   60S ribosomal protein L19, putative
Leishmania mexicana LmxM.06.0415   60S ribosomal protein L19, putative
Leishmania mexicana LmxM.06.0410   60S ribosomal protein L19, putative
Loa Loa (eye worm) LOAG_10701   hypothetical protein
Mus musculus ENSMUSG00000017404   ribosomal protein L19
Mus musculus 102641283   60S ribosomal protein L19-like
Neospora caninum NCLIV_041780   LSU ribosomal protein L19E, related
Oryza sativa 4333317   Os03g0579300
Oryza sativa 4332773   Os03g0337800
Plasmodium berghei PBANKA_1229200   60S ribosomal protein L19, putative
Plasmodium falciparum PF3D7_0614500   60S ribosomal protein L19
Plasmodium knowlesi PKNH_1135500   60S ribosomal protein L19, putative
Plasmodium vivax PVX_113860   60S ribosomal protein L19, putative
Plasmodium yoelii PY05486   60S ribosomal protein L19
Saccharomyces cerevisiae YBL027W   ribosomal 60S subunit protein L19B
Saccharomyces cerevisiae YBR084C-A   ribosomal 60S subunit protein L19A
Schistosoma japonicum Sjp_0086580   expressed protein
Schistosoma japonicum Sjp_0086570   IPR009041,Proteinase inhibitor, PMP and SGCI,domain-containing
Schistosoma japonicum Sjp_0304140   ko:K02885 large subunit ribosomal protein L19e, putative
Schistosoma mansoni Smp_171570   60S ribosomal protein L19
Schmidtea mediterranea mk4.000008.01   60S ribosomal protein L19
Trypanosoma brucei gambiense Tbg972.7.5730   60S ribosomal protein L19, putative
Trypanosoma brucei gambiense Tbg972.7.5750   60S ribosomal protein L19, putative
Trypanosoma brucei Tb927.7.5020   60S ribosomal protein L19, putative
Trypanosoma brucei Tb927.7.5000   60S ribosomal protein L19, putative
Trypanosoma congolense TcIL3000_7_4220   60S ribosomal protein L19, putative
Trypanosoma congolense TcIL3000_7_4200   60S ribosomal protein L19, putative
Trypanosoma cruzi TcCLB.509149.60   60S ribosomal protein L19, putative
Trypanosoma cruzi TcCLB.509149.40   60S ribosomal protein L19, putative
Trypanosoma cruzi TcCLB.508175.329   60S ribosomal protein L19, putative
Trypanosoma cruzi TcCLB.508175.309   60S ribosomal protein L19, putative
Toxoplasma gondii TGME49_289530   ribosomal protein RPL19
Theileria parva TP03_0163   60S ribosomal protein L19, putative
Trichomonas vaginalis TVAG_185160   60S ribosomal protein L19, putative
Trichomonas vaginalis TVAG_006170   60S ribosomal protein L19, putative
Trichomonas vaginalis TVAG_185180   60S ribosomal protein L19, putative
Trichomonas vaginalis TVAG_185170   60S ribosomal protein L19, putative

Essentiality

PF3D7_0614500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.5000 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.5000 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.5000 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.5000 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C09D4.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C09D4.5 Caenorhabditis elegans larval arrest wormbase
CELE_C09D4.5 Caenorhabditis elegans larval lethal wormbase
CELE_C09D4.5 Caenorhabditis elegans sterile wormbase
CELE_C09D4.5 Caenorhabditis elegans terminal arrest variable wormbase
TGME49_289530 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Saccharomyces cerevisiae ribosomal 60S subunit protein L19B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0032 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_0614500 (Plasmodium falciparum), 60S ribosomal protein L19
Title for this comment
Comment